Searchable abstracts of presentations at key conferences in endocrinology

ea0015p276 | Reproduction | SFEBES2008

Early female sexual differentiation in humans is androgen-responsive

Asby Daniel , Wood Peter , Hanley Neil

Mammalian differentiation of the external genitalia must be strictly dimorphic for reproductive success. In humans, this is established by a complex interplay of genetic and hormonal factors during 7–12 weeks post-conception (wpc). Despite being fundamental to normal human biology, understanding of human sexual differentiation remains limited. Our objective was to define the onset and regulation of androgen biosynthesis in the human fetal testis and correlate this to diff...